Copy a blank template (system_file="template") file to the working directory or an example by specifying the following:
"template"- Empty system file template"adapt"- Parent/metabolite model taken from the adapt manual used in estimation examples [ADAPT]"two_cmt_cl"- Two compartment model parameterized in terms of clearances"one_cmt_cl"- One compartment model parameterized in terms of clearances"two_cmt_micro"- Two compartment model parameterized in terms of rates (micro constants)"one_cmt_micro"- One compartment model parameterized in terms of rates (micro constants)"mab_pk"- General compartmental model of mAb PK from Davda 2014 [DG]"pbpk"- PBPK model of mAb disposition in mice from Shah 2012 [SB]"pbpk_template"- System parameters from Shah 2012 [SB] have been defined for all species along with the set notation to be used as a template for developing models with physiological parameters"pwc"- Example showing how to make if/then or piece-wise continuous variables"tmdd"- Model of antibody with target-mediated drug disposition"tumor"- Transit tumor growth model taken from Lobo 2002 [LB]
Usage
system_new(
file_name = "system.txt",
system_file = "template",
overwrite = FALSE,
output_directory = getwd()
)Arguments
- file_name
name of the new file to create
- system_file
name of the system file to copy
- overwrite
if
TRUEthe new system file will overwrite any existing files present- output_directory
getwd()directory where system file will be placed
Details
References
[ADAPT] Adapt 5 Users Guide https://bmsr.usc.edu/files/2013/02/ADAPT5-User-Guide.pdf
[DG] Davda et. al. mAbs (2014) 6(4):1094-1102 doi:10.4161/mabs.29095
[LB] Lobo, E.D. & Balthasar, J.P. AAPS J (2002) 4, 212-222 doi:10.1208/ps040442
[SB] Shah, D.K. & Betts, A.M. JPKPD (2012) 39 (1), 67-86 doi:10.1007/s10928-011-9232-2
Examples
# \donttest{
# To create an example system file named example_system.txt:
system_new(system_file = "mab_pk",
file_name = "system_example.txt",
overwrite = TRUE,
output_directory = tempdir())
#> [1] TRUE
# }
